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The increase in opioid overdose deaths has been dramatic opioids are now responsible for 49 000 drug overdose deaths overall in the US in. The sedated unconscious patient may be affected by central nervous system ( CNS) depressants such as opiates, g- hydroxybutyrate ( GHB) benzodiazepines.

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Overdose deaths involving ntext The rate of prescription opioid– related overdose death increased substantially in the United States over the past decade. The opioid epidemic opioid crisis is the rapid increase in the use of prescription , non- prescription opioid drugs in the United States , Canada beginning in the late 1990s continuing throughout the next two decades.

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